Ipe Binil Itty, Mahima S, Thomas K George
Photosciences and Photonics Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India.
J Am Chem Soc. 2003 Jun 18;125(24):7174-5. doi: 10.1021/ja0341182.
A photoswitchable double-shell structure on Au nanoparticles, consisting of photochromic spiropyran as the first shell, which regulates the assembly and release of an outer shell of amino acid derivatives upon irradiation, is being reported for the first time. The light-regulated changes in the topographic properties of spiropyran-capped Au nanoparticles (i.e., interconversion between the zwitterionic and neutral forms) are exploited for the assembly and release of amino acid-based therapeutic agents such as l-DOPA.
首次报道了金纳米颗粒上的一种光开关双壳结构，其由光致变色螺吡喃作为第一壳层组成，该壳层在光照下调节氨基酸衍生物外壳的组装和释放。利用螺吡喃包覆的金纳米颗粒形貌特性的光调节变化（即两性离子形式和中性形式之间的相互转化）来组装和释放基于氨基酸的治疗剂，如左旋多巴。
