Zaichick Vladimir, Tzaphlidou Margaret
Department of Nuclear Medicine, Medical Radiological Research Center, 249020 Obninsk, Kaluga Region, Russia.
Appl Radiat Isot. 2003 Jun;58(6):623-7. doi: 10.1016/s0969-8043(03)00092-7.
The Ca and P concentrations as well as the Ca/P ratio were estimated in intact trabecular bone samples from the femoral neck of healthy humans, 34 women and 44 men, aged from 15 to 55 years, using instrumental neutron activation analysis. The mean values (M+/-SD) for the investigated parameters (on a dry-weight basis) were: 12.1+/-3.0%, 5.94+/-1.71%, 2.07+/-0.25 and 10.9+/-2.5%, 5.30+/-1.23%, 2.07+/-0.22 for females and males, respectively. A statistically significant (p</=0.05) decrease of Ca concentration with age was found only for males while the P concentration and the Ca/P ratio were not affected by age. No statistically significant sex-related differences were observed in any of the parameters. The mean values for Ca, P and the Ca/P ratio lay close to the median of the very wide range of published data. The individual variation for the Ca/P ratio in trabecular bone from the healthy human femoral neck was lower than those for Ca and P separately. This suggests that the specificity of the Ca/P ratio is better than that of Ca and P concentrations and may be more reliable for the diagnosis of bone disorders.
采用仪器中子活化分析法，对年龄在15至55岁之间的34名女性和44名男性健康人的股骨颈完整小梁骨样本中的钙（Ca）和磷（P）浓度以及钙磷比进行了估算。所研究参数（以干重计）的平均值（M±SD）分别为：女性为12.1±3.0%、5.94±1.71%、2.07±0.25，男性为10.9±2.5%、5.30±1.23%、2.07±0.22。仅发现男性的钙浓度随年龄增长有统计学显著下降（p≤0.05），而磷浓度和钙磷比不受年龄影响。在任何参数中均未观察到与性别相关的统计学显著差异。钙、磷和钙磷比的平均值接近已发表数据非常广泛范围的中位数。健康人股骨颈小梁骨中钙磷比的个体差异低于钙和磷各自的个体差异。这表明钙磷比的特异性优于钙和磷浓度，可能对骨疾病的诊断更可靠。
