Tzaphlidou Margaret, Zaichick Vladimir
Laboratory of Medical Physics, Medical School, Ioannina University, 45110 Ioannina, Greece.
Biol Trace Elem Res. 2003 Summer;93(1-3):63-74. doi: 10.1385/BTER:93:1-3:63.
Calcium and phosphorus concentrations as well as the Ca/P ratio were estimated in intact rib bone samples from healthy humans, 37 women and 45 men, aged 15-55 yr. For Ca and P concentration measurements, instrumental neutron activation analysis was used. The mean values (mean +/- SD) for the investigated parameters were 19.3 +/- 4.5% of dry bone weight, 8.42 +/- 2.14% of dry bone weight, and a ratio of 2.33 +/- 0.34, respectively. Statistically significant differences for the above parameters were not observed to be related either to age or sex. The mean values for Ca, P, and the Ca/P ratio were within a very wide range of published data and close to their medians. The individual variation for the Ca/P ratio in rib bone from healthy humans was lower than those for Ca and P taken separately. An indication is that the specificity of the Ca/P ratio improves upon that for Ca and P concentrations and may be more reliable in the diagnosis of bone disorders.
对年龄在15 - 55岁的37名女性和45名男性健康人的完整肋骨样本中的钙、磷浓度以及钙/磷比值进行了估算。对于钙和磷浓度的测量，采用了仪器中子活化分析。所研究参数的平均值（平均值±标准差）分别为干骨重量的19.3±4.5%、干骨重量的8.42±2.14%以及比值2.33±0.34。未观察到上述参数的统计学显著差异与年龄或性别有关。钙、磷以及钙/磷比值的平均值在已发表数据的非常广泛范围内，且接近其中位数。健康人肋骨中钙/磷比值的个体差异低于单独的钙和磷的个体差异。这表明钙/磷比值的特异性优于钙和磷浓度的特异性，在骨疾病诊断中可能更可靠。
