Noor Zairin, Sumitro Sutiman Bambang, Hidayat Mohammad, Rahim Agus Hadian, Sabarudin Akhmad, Umemura Tomonari
Department of Orthopaedics, Ulin General Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70232, Indonesia.
ScientificWorldJournal. 2012;2012:372972. doi: 10.1100/2012/372972. Epub 2012 Apr 30.
Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosis and normal bones was studied by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). The influence of these elements on bone metabolic processes is also discussed. Inclusion criteria of bone samples consist of postmenopausal woman, trabecular bone fracture, normal and osteoporosis BMD value, and no history of previous disease. The results showed that the concentration of B, Al, S, V, Co, Mo, Te, Ba, La, Ni, As, and Ca/P ratio is higher in osteoporosis than normal. These atomic minerals have negative role to imbalance between bone resorption and bone formation activity. Conversely, concentrations of Na, Mg, P, K, Ca, Cr, Pd, Ag, Mn, Fe, Cu, Zn, Rb, Sr, Pb, and Se are lower in osteoporosis than in normal bones. Among these atoms, known to have important roles in bone structure, we found involvement of atomic mineral and calcium which are considerable to contribute to osteoporotic phenomena.
临床研究表明，负钙平衡与低骨量、快速骨质流失和高骨折率相关。然而，一些研究表明，作为骨折骨质疏松症的危险因素，不仅钙参与了骨骼强化。因此，在本报告中，通过高分辨率电感耦合等离子体质谱法（HR-ICP-MS）研究了骨质疏松症骨骼和正常骨骼中金属和非金属元素的差异。还讨论了这些元素对骨代谢过程的影响。骨样本的纳入标准包括绝经后女性、小梁骨骨折、正常和骨质疏松症的骨密度值，且无既往病史。结果表明，骨质疏松症患者中硼、铝、硫、钒、钴、钼、碲、钡、镧、镍、砷的浓度以及钙/磷比值高于正常水平。这些原子矿物质对骨吸收和骨形成活动之间的失衡具有负面作用。相反，骨质疏松症患者中钠、镁、磷、钾、钙、铬、钯、银、锰、铁、铜、锌、铷、锶、铅和硒的浓度低于正常骨骼。在这些已知对骨骼结构有重要作用的原子中，我们发现原子矿物质和钙的参与对骨质疏松现象有相当大的影响。
