Jaber M A, Porter S R, Speight P, Eveson J W, Scully C
Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray's Inn Road, London WC1X 8LD, UK.
Oral Oncol. 2003 Sep;39(6):589-96. doi: 10.1016/s1368-8375(03)00045-9.
To detail the clinical presentation of oral epithelial dysplasia in a large cohort of residents in western Europe. Descriptive statistical analysis of the data were calculated using chi-square and Fisher's exact tests. Oral epithelial dysplasia manifested typically as a white or mixed red and white lesion on the tongue, buccal mucosa or floor of mouth. The peak age of presentation of oral epithelial dysplasia was the 6th decade. Most clinically detected lesions had only mild oral epithelial dysplasia. Although uncommon, lesions with severe dysplasia were most likely to arise on the floor of mouth or lateral border of tongue. Oral epithelial dysplasia is likely to manifest as a solitary white patch, but it is not possible to accurately predict the likely degree of dysplasia from the clinical features of such lesions.
详述西欧大量居民口腔上皮发育异常的临床表现。使用卡方检验和费舍尔精确检验对数据进行描述性统计分析。口腔上皮发育异常通常表现为舌、颊黏膜或口底的白色病变或红白相间的混合性病变。口腔上皮发育异常的发病高峰年龄为60岁。大多数临床检测到的病变仅有轻度口腔上皮发育异常。尽管不常见,但重度发育异常的病变最有可能出现在口底或舌侧缘。口腔上皮发育异常可能表现为单个白色斑块,但无法根据此类病变的临床特征准确预测发育异常的可能程度。