辣椒素脱敏对豚鼠鼻腔中甲苯二异氰酸酯诱导的鼻过敏样症状及组胺释放的影响。
Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs.
作者信息
Abe Y, Takeda N, Irifune M, Ogino S, Kalubi B, Imamura I, Fukui H, Wada H, Matsunaga T
机构信息
Department of Otolaryngology, Osaka University Medical School, Japan.
出版信息
Acta Otolaryngol. 1992;112(4):703-9. doi: 10.3109/00016489209137463.
Intranasal application of toluene diisocyanate (TDI) induced nasal allergy-like symptoms of sneezing and watery rhinorrhea and decreased the histamine content of the nasal mucosa in guinea pigs. However, in the animals pretreated with capsaicin (capsaicin desensitization) before sensitization with TDI, nasal allergy-like symptoms were not induced. Capsaicin desensitization also inhibited histamine release in the nasal mucosa induced by TDI. These findings suggest that antidromic impulses of capsaicin-sensitive sensory nerves stimulated by TDI cause histamine release from mast cells in the nasal mucosa, resulting in nasal discharge and sneezing in guinea pigs. Thus neurogenic inflammation via an axon reflex in the nose may contribute to the pathogenesis of vasomotor rhinitis.
经鼻应用甲苯二异氰酸酯（TDI）可诱发豚鼠出现类似鼻过敏的打喷嚏和水样鼻溢症状，并降低鼻黏膜中的组胺含量。然而，在用TDI致敏前先用辣椒素预处理（辣椒素脱敏）的动物中，未诱发类似鼻过敏的症状。辣椒素脱敏还抑制了TDI诱导的鼻黏膜组胺释放。这些发现表明，TDI刺激的辣椒素敏感感觉神经的逆向冲动导致鼻黏膜肥大细胞释放组胺，从而引起豚鼠鼻分泌物增多和打喷嚏。因此，鼻子中通过轴突反射引起的神经源性炎症可能在血管运动性鼻炎的发病机制中起作用。
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