Zaczyńska E, Błach-Olszewska Z, Feldmane G, Duks A, Mordarska H, Bizuniak I, Cembrzyńska-Nowak M, Lugowski C
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Acta Virol. 1992 Mar;36(2):121-8.
The effect of different natural and synthetic immunomodulators on the spontaneous interferon (IFN) synthesis by freshly isolated resident peritoneal cells of BALB/c, NZB and C3H mice was investigated. Actinomycetal glycolipids isolated from Curtobacterium betae, Faenia rectivirgula, Rothia dentocariosa and Saccharopolyspora hirsuta at the concentration 1-20 micrograms/ml were found to potentiate the IFN synthesis by the peritoneal cells of BALB/c mice. Similar results were obtained when dsRNA, LPS of Shigella sonnei and lipid A isolated from the LPS were used. The effect of potentiation of the physiological IFN production by the immunomodulators was observed also in the cells of C3H and NZB mice. In contrast, the inhibition of the IFN synthesis was observed when the peritoneal cells of BALB/c and NZB mice were treated with imuthiol at concentration 0.1-10 micrograms/ml. Thymomodulin (TFX-Polfa) at concentration of 1-100 micrograms/ml had no effect on the spontaneous IFN production.
研究了不同天然和合成免疫调节剂对BALB/c、NZB和C3H小鼠新鲜分离的腹腔常驻细胞自发干扰素（IFN）合成的影响。发现从甜菜短杆菌、直链镰刀菌、龋齿罗氏菌和多毛糖多孢菌中分离出的放线菌糖脂，浓度为1-20微克/毫升时，可增强BALB/c小鼠腹腔细胞的IFN合成。当使用双链RNA、宋内志贺氏菌的脂多糖（LPS）以及从该LPS中分离出的脂质A时，也获得了类似结果。在C3H和NZB小鼠的细胞中也观察到免疫调节剂增强生理性IFN产生的作用。相反，当用浓度为0.1-10微克/毫升的依木硫醇处理BALB/c和NZB小鼠的腹腔细胞时，观察到IFN合成受到抑制。浓度为1-100微克/毫升的胸腺调节素（TFX-波耳发）对自发IFN产生没有影响。
