Rauch Scott L, Shin Lisa M, Segal Ethan, Pitman Roger K, Carson Margaret A, McMullin Katherine, Whalen Paul J, Makris Nikos
Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St., Bldg 149, CNY-9, Charlestown, MA 02129, USA.
Neuroreport. 2003 May 23;14(7):913-6. doi: 10.1097/01.wnr.0000071767.24455.10.
Different subterritories of anterior cingulate cortex (ACC) and adjacent ventromedial frontal cortex have been shown to serve distinct functions. This scheme has influenced contemporary pathophysiologic models of psychiatric disorders. Prevailing neurocircuitry models of post-traumatic stress disorder (PTSD) implicate dysfunction within pregenual ACC and subcallosal cortex (SC), as well as amygdala and hippocampus. In the current study, cortical parcellation of magnetic resonance imaging data was performed to test for volumetric differences in pregenual ACC and SC, between women with PTSD and trauma-exposed women without PTSD. The PTSD group exhibited selectively decreased pregenual ACC and SC volumes. These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD.
前扣带回皮质（ACC）和相邻的腹内侧前额叶皮质的不同亚区域已被证明具有不同的功能。这一模式影响了当代精神疾病的病理生理模型。创伤后应激障碍（PTSD）流行的神经回路模型表明膝前扣带回皮质和胼胝体下皮质（SC）以及杏仁核和海马体存在功能障碍。在本研究中，对磁共振成像数据进行皮质分区，以测试PTSD女性与有创伤暴露但无PTSD的女性之间膝前扣带回皮质和SC的体积差异。PTSD组表现出膝前扣带回皮质和SC体积选择性减少。这些结果与关于额叶皮质功能和结构解剖的当代模式一致，并提示PTSD存在特定的区域皮质病理。
