Corbo Vincent, Clément Marie-Hélène, Armony Jorge L, Pruessner Jens C, Brunet Alain
Douglas Hospital Research Center, Department of Psychiatry, Montreal, Quebec, Canada.
Biol Psychiatry. 2005 Jul 15;58(2):119-24. doi: 10.1016/j.biopsych.2005.02.032.
Two studies found morphological differences in the anterior cingulate cortex (ACC) of individuals with chronic posttraumatic stress disorder (PTSD). We sought to replicate and extend these findings in a sample of individuals with acute PTSD.
The ACCs of individuals with acute PTSD (n = 14) and matched healthy control subjects (n = 14) were compared using voxel-based morphometry (VBM), semi-automated volumetric analyses, and probabilistic maps. Posttraumatic stress disorder diagnosis was ascertained by a psychologist using a structured interview.
Voxel-based morphometry analyses revealed significantly less gray-matter density in the right pregenual ACC and in the left insula of the PTSD group. However, volumetric analyses of the ACC revealed no significant differences between groups. Probabilistic maps of the labels of the pregenual ACC indicated that the difference between groups in gray matter density was due to shape differences.
Although there are no volumetric differences in the ACC of acute PTSD individuals compared with normal control subjects, significant shape differences exist, which might indicate volumetric differences in the surrounding structures.
两项研究发现，患有慢性创伤后应激障碍（PTSD）的个体前扣带回皮质（ACC）存在形态学差异。我们试图在急性PTSD个体样本中重复并扩展这些发现。
使用基于体素的形态测量法（VBM）、半自动体积分析和概率图谱，比较了急性PTSD个体（n = 14）和匹配的健康对照受试者（n = 14）的ACC。创伤后应激障碍的诊断由心理学家通过结构化访谈确定。
基于体素的形态测量分析显示，PTSD组右侧膝前ACC和左侧岛叶的灰质密度显著降低。然而，ACC的体积分析显示两组之间没有显著差异。膝前ACC标签的概率图谱表明，两组之间灰质密度的差异是由于形状差异。
尽管与正常对照受试者相比，急性PTSD个体的ACC没有体积差异，但存在显著的形状差异，这可能表明周围结构存在体积差异。
