Zanetti Flavia, Rodríguez Marianela, King Daniel J, Capua Ilaria, Carrillo Elisa, Seal Bruce S, Berinstein Analía
Instituto de Biotecnología, Centro de Investigaciones en Ciencias Veterinarias y Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, Castelar, Buenos Aires, Argentina.
Virus Genes. 2003;26(2):199-206. doi: 10.1023/a:1023495615729.
The matrix protein gene was cloned and sequenced for several recent isolates of avian paramyxovirus type 1 (APMV-1). Specifically, isolates from pigeons and doves, members of the Columbidae family were examined. APMV-1 is the causative agent of Newcastle disease and the virus is associated with disease among a diverse number of avian species. Newcastle disease virus (NDV) isolates from pigeons have also been classified as pigeon paramyxovirus type 1 (PPMV-1). Matrix protein gene sequences for PPMV-1 isolates clustered together as a group relative to isolates from other species phylogenetically. However, there were also isolates from pigeons or doves that grouped with APMV-1 isolates from other species. This indicates that PPMV-1 may be circulating among Columbidae members as a distinct lineage, but that these avian species may also harbor other NDV strains as well. Of particular interest was a dove isolate from Europe that had an aberrant fusion protein cleavage site and was an outlying member phylogenetically between the two major groups of APMV-1 isolates.
对几种近期的禽1型副粘病毒（APMV-1）分离株的基质蛋白基因进行了克隆和测序。具体而言，对鸽形目成员鸽子和鸠的分离株进行了检测。APMV-1是新城疫的病原体，该病毒与多种禽类的疾病有关。来自鸽子的新城疫病毒（NDV）分离株也被归类为鸽1型副粘病毒（PPMV-1）。相对于其他物种的分离株，PPMV-1分离株的基质蛋白基因序列在系统发育上聚为一组。然而，也有来自鸽子或鸠的分离株与其他物种的APMV-1分离株归为一类。这表明PPMV-1可能作为一个独特的谱系在鸽形目成员中传播，但这些禽类也可能携带其他NDV毒株。特别令人感兴趣的是来自欧洲的一株鸠分离株，其融合蛋白裂解位点异常，在系统发育上是APMV-1分离株两大主要群体之间的一个外围成员。
