Walker M C, Ferguson S E, Allen V M
Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, K1H 8L6.
Cochrane Database Syst Rev. 2003;2003(2):CD003580. doi: 10.1002/14651858.CD003580.
Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin administration in pregnancy may reduce the risk of these events.
The objective of this review was to assess the effects of heparin on pregnancy outcomes for women with a thrombophilia.
We searched the Cochrane Pregnancy and Childbirth Group trials register (July 2002), MEDLINE, EMBASE, CINAHL, Scidex (via OVID Technologies - July 2002) and reference lists and personal files.
Randomized controlled trials comparing heparin with placebo or no treatment, or randomized controlled trials comparing any two treatments. Quasi randomized studies would be included.
Data would be abstracted from identified studies and recorded on a paper form by two reviewers.
No studies were included.
REVIEWER'S CONCLUSIONS: There are no completed trials to determine the effects of heparin on pregnancy outcomes for women with a thrombophilia.
血栓形成倾向与血栓形成事件的易感性相关，已被认为与不良产科结局有关，如胎儿生长受限、死产、重度早发型子痫前期和胎盘早剥。孕期使用肝素可能会降低这些事件的风险。
本综述的目的是评估肝素对患有血栓形成倾向的女性妊娠结局的影响。
我们检索了Cochrane妊娠与分娩组试验注册库（2002年7月）、MEDLINE、EMBASE、CINAHL、Scidex（通过OVID技术——2002年7月）以及参考文献列表和个人资料。
比较肝素与安慰剂或不治疗的随机对照试验，或比较任意两种治疗方法的随机对照试验。将纳入半随机研究。
数据将从已确定的研究中提取，并由两名综述员记录在纸质表格上。
未纳入任何研究。
尚无已完成的试验来确定肝素对患有血栓形成倾向的女性妊娠结局的影响。
