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Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial.复发性流产患者血栓前状态的预防治疗：有无血栓形成倾向的妇女。HABENOX：一项随机多中心试验。
Thromb Haemost. 2011 Feb;105(2):295-301. doi: 10.1160/TH10-05-0334. Epub 2010 Nov 23.
2
Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial.低分子量肝素与阿司匹林治疗复发性流产：随机对照HepASA试验的结果
J Rheumatol. 2009 Feb;36(2):279-87. doi: 10.3899/jrheum.080763).
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Safety and effectiveness of tinzaparin sodium in the management of recurrent pregnancy loss.替扎肝素钠治疗复发性流产的安全性和有效性。
Clin Exp Obstet Gynecol. 2007;34(3):143-5.
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Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial.孕期长期使用达肝素与骨密度降低无关：一项随机对照试验的子研究
J Thromb Haemost. 2007 Aug;5(8):1600-6. doi: 10.1111/j.1538-7836.2007.02634.x.
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The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial.达肝素对血栓形成倾向女性孕期凝血激活的影响。一项随机试验。
Thromb Haemost. 2007 Jul;98(1):163-71.
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Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study.依诺肝素对复发性流产合并血栓形成倾向女性晚期妊娠并发症及新生儿结局的影响：来自Live-Enox研究的结果
Fertil Steril. 2005 Sep;84(3):770-3. doi: 10.1016/j.fertnstert.2005.03.048.
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Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study.两剂依诺肝素治疗血栓形成倾向和复发性流产女性的疗效与安全性：LIVE-ENOX研究
J Thromb Haemost. 2005 Feb;3(2):227-9. doi: 10.1111/j.1538-7836.2004.01090.x.
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Thromboprophylaxis and pregnancy: two randomized controlled pilot trials that used low-molecular-weight heparin.血栓预防与妊娠：两项使用低分子量肝素的随机对照试验。
Am J Obstet Gynecol. 2004 Oct;191(4):1296-303. doi: 10.1016/j.ajog.2004.03.039.
9
Increased frequency of genetic thrombophilia in women with complications of pregnancy.妊娠并发症女性中遗传性血栓形成倾向的频率增加。
N Engl J Med. 1999 Jan 7;340(1):9-13. doi: 10.1056/NEJM199901073400102.
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Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation.
Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1605-11. doi: 10.1016/s0002-9378(98)70033-x.

Heparin for pregnant women with acquired or inherited thrombophilias.

作者信息

Walker M C, Ferguson S E, Allen V M

机构信息

Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, K1H 8L6.

出版信息

Cochrane Database Syst Rev. 2003;2003(2):CD003580. doi: 10.1002/14651858.CD003580.

DOI:10.1002/14651858.CD003580
PMID:12804477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7388932/
Abstract

BACKGROUND

Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin administration in pregnancy may reduce the risk of these events.

OBJECTIVES

The objective of this review was to assess the effects of heparin on pregnancy outcomes for women with a thrombophilia.

SEARCH STRATEGY

We searched the Cochrane Pregnancy and Childbirth Group trials register (July 2002), MEDLINE, EMBASE, CINAHL, Scidex (via OVID Technologies - July 2002) and reference lists and personal files.

SELECTION CRITERIA

Randomized controlled trials comparing heparin with placebo or no treatment, or randomized controlled trials comparing any two treatments. Quasi randomized studies would be included.

DATA COLLECTION AND ANALYSIS

Data would be abstracted from identified studies and recorded on a paper form by two reviewers.

MAIN RESULTS

No studies were included.

REVIEWER'S CONCLUSIONS: There are no completed trials to determine the effects of heparin on pregnancy outcomes for women with a thrombophilia.

摘要