感染与自发性颈动脉夹层的风险：一项病例对照研究。
Infection and the risk of spontaneous cervical artery dissection: a case-control study.
作者信息
Guillon Benoît, Berthet Karine, Benslamia Lamia, Bertrand Marion, Bousser Marie-Germaine, Tzourio Christophe
机构信息
Department of Neurology, Nantes Hospital, Nantes, France.
出版信息
Stroke. 2003 Jul;34(7):e79-81. doi: 10.1161/01.STR.0000078309.56307.5C. Epub 2003 Jun 12.
BACKGROUND AND PURPOSE
Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study.
METHODS
Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event.
RESULTS
Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection.
CONCLUSIONS
Recent infection is a risk factor and could be a trigger for SCAD.
背景与目的
多种体质和环境危险因素可能与自发性颈动脉夹层（SCAD）的发生有关。本研究在一项基于医院的病例对照研究中探讨近期感染与SCAD之间的关联。
方法
两个神经科前瞻性连续招募了47例SCAD患者和52例因其他原因导致缺血性卒中的患者。使用专门设计的问卷评估血管事件发生前一个月内可能发生的急性感染病史。
结果
SCAD患者中急性感染更为常见（31.9%），高于对照组（13.5%）（粗比值比，3.0；95%置信区间，1.1至8.2；P=0.032）。这种关联在多条动脉夹层（比值比，6.4）患者中比单条动脉夹层（比值比，2.1）患者更强。
结论
近期感染是SCAD的一个危险因素，可能是其触发因素。
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