Nathan D M
Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, Boston.
Drugs. 1992;44 Suppl 3:39-46. doi: 10.2165/00003495-199200443-00006.
Insulin therapy has been lifesaving for patients with insulin-dependent diabetes mellitus. Unfortunately, longer lifespan has unmasked microvascular, neurological and macrovascular complications that result in profound morbidity and increased mortality. Driven by the conviction that better physiological control of glycaemic levels will prevent and/or ameliorate long term complications, and by the desire to make diabetes care as user-friendly as possible, clinical research efforts have led to the development of new treatment methods with the aim of achieving near normal metabolic control. Such methods include the use of self monitoring, multiple daily insulin injection regimens, external and implantable insulin pumps, and whole organ pancreas and isolated islet cell transplantation. In addition, dietary manipulation, including the use of alpha-glucosidase inhibitors, has played a role in controlling glycaemia.
胰岛素治疗对胰岛素依赖型糖尿病患者来说是救命的。不幸的是，更长的寿命使微血管、神经和大血管并发症显现出来，这些并发症会导致严重的发病率和死亡率增加。出于更好地生理控制血糖水平将预防和/或改善长期并发症的信念，以及使糖尿病护理尽可能方便用户的愿望，临床研究努力导致了旨在实现接近正常代谢控制的新治疗方法的发展。这些方法包括自我监测的使用、每日多次胰岛素注射方案、外部和植入式胰岛素泵，以及全器官胰腺和分离的胰岛细胞移植。此外，饮食控制，包括使用α-葡萄糖苷酶抑制剂，在控制血糖方面也发挥了作用。
