Jacobs Stef, Boccarella Giorgio, van den Berg Pieter, Van Dijck Patrick, Carolus Hans
Laboratory of Molecular Cell Biology, Department of Biology, KU Leuven, Leuven, Belgium.
Evolutionary Modelling Group, Department of Biology, KU Leuven, Leuven, Belgium.
NPJ Antimicrob Resist. 2024 Dec 12;2(1):48. doi: 10.1038/s44259-024-00064-1.
Exploring the dynamics and molecular mechanisms of antimicrobial drug resistance provides critical insights for developing effective strategies to combat it. This review highlights the potential of experimental evolution methods to study resistance in pathogenic fungi, drawing on insights from bacteriology and innovative approaches in mycology. We emphasize the versatility of experimental evolution in replicating clinical and environmental scenarios and propose that incorporating evolutionary modelling can enhance our understanding of antifungal resistance evolution. We advocate for a broader application of experimental evolution in medical mycology to improve our still limited understanding of drug resistance in fungi.
探索抗菌药物耐药性的动态变化和分子机制，为制定有效的应对策略提供了关键见解。本综述借鉴细菌学的见解和真菌学的创新方法，强调了实验进化方法在研究致病真菌耐药性方面的潜力。我们强调实验进化在复制临床和环境场景方面的多功能性，并提出纳入进化模型可以增强我们对抗真菌耐药性进化的理解。我们主张在医学真菌学中更广泛地应用实验进化，以改善我们对真菌耐药性仍然有限的理解。
