Passamonti Marco, Boore Jeffrey L, Scali Valerio
Dipartimento di Biologia Evoluzionistica Sperimentale, Università degli Studi di Bologna, Italy.
Genetics. 2003 Jun;164(2):603-11. doi: 10.1093/genetics/164.2.603.
Doubly uniparental inheritance (DUI) provides an intriguing system for addressing aspects of molecular evolution and intermolecular recombination of mitochondrial DNA. For this reason, a large sequence analysis has been performed on Tapes philippinarum (Bivalvia, Veneridae), which has mitochondrial DNA heteroplasmy that is consistent with a DUI. The sequences of a 9.2-kb region (containing 29 genes) from 9 individuals and the sequences of a single gene from another 44 individuals are analyzed. Comparisons suggest that the two sex-related mitochondrial genomes do not experience a neutral pattern of divergence and that selection may act with varying strength on different genes. This pattern of evolution may be related to the long, separate history of M and F genomes within their tissue-specific "arenas." Moreover, our data suggest that recombinants, although occurring in soma, may seldom be transmitted to progeny in T. philippinarum.
双单亲遗传（DUI）为研究线粒体DNA的分子进化和分子间重组提供了一个有趣的系统。基于此，对菲律宾蛤仔（双壳纲，帘蛤科）进行了大规模序列分析，其线粒体DNA异质性与双单亲遗传一致。分析了9个个体的9.2kb区域（包含29个基因）的序列以及另外44个个体的单个基因的序列。比较结果表明，两个与性别相关的线粒体基因组并未经历中性的分化模式，并且选择可能对不同基因发挥不同强度的作用。这种进化模式可能与M和F基因组在其组织特异性“区域”内长期独立的历史有关。此外，我们的数据表明，重组体虽然在体细胞中出现，但在菲律宾蛤仔中很少传递给后代。
