Zeytinoglu H, Incesu Z, Baser K H C
Department of Biology, Faculty of Sciences, Anadolu University, Eskisehir, Turkey.
Phytomedicine. 2003 May;10(4):292-9. doi: 10.1078/094471103322004785.
Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional distillation of Origanum onites L. essential oil, on DNA synthesis of N-ras transformed myoblast cells, CO25. Incubation of the cells with different doses of carvacrol prevented DNA synthesis in the growth medium and ras-activating medium, which contains dexamethasone. This result demonstrates that carvacrol inhibits growth of myoblast cells even after activation of mutated N-ras oncogene, suggesting the possibility that carvacrol may find application in cancer therapy.
单萜是在多种植物的精油中发现的膳食成分。许多这类单萜具有抗肿瘤活性。我们研究了通过分馏牛至叶精油获得的香芹酚对N-ras转化的成肌细胞CO25的DNA合成的影响。用不同剂量的香芹酚孵育细胞可阻止生长培养基和含有地塞米松的ras激活培养基中的DNA合成。这一结果表明，即使在突变的N-ras癌基因激活后，香芹酚仍能抑制成肌细胞的生长，这表明香芹酚可能在癌症治疗中得到应用。
