Grønbaek H, Thorlacius-Ussing O
Institute of Neurobiology, University of Aarhus, Denmark.
Biol Trace Elem Res. 1992 Nov;35(2):119-27. doi: 10.1007/BF02783724.
The aim of the present study is to investigate the accumulation and retention of organic and inorganic selenium in the central nervous system (CNS) of the rat. Selenium accumulation was investigated after oral treatment (3.0 mg Se/L drinking water) or ip injection (1.7 mg Se/kg body wt) of rats exposed to 75-Se L-selenomethionine (SeMeth) or sodium selenite (NaSe). Significant higher concentrations were observed after exposure to organic compared to inorganic selenium after oral as well as ip administration. Highest concentrations in both experiments were observed in cerebellum followed by the nearly identical levels in the cerebral hemisphere and spinal cord independent of the chemical form of selenium or the route of administration. The difference in concentrations observed between the different parts of the CNS investigated in each group were, however, not significant. Retention of selenium in the CNS was investigated after a single ip injection (1.7 mg Se/kg body wt) of 75-Se SeMeth or NaSe. In both groups, we observed an initial fast excretion phase followed by a slower excretion phase resembling a first-order reaction. Organic selenium disappeared much slower from all parts of the central nervous system compared to NaSe after a single injection.
本研究的目的是调查大鼠中枢神经系统（CNS）中有机硒和无机硒的积累与留存情况。在给大鼠口服（3.0毫克硒/升饮用水）或腹腔注射（1.7毫克硒/千克体重）75-硒-L-硒代蛋氨酸（SeMeth）或亚硒酸钠（NaSe）后，对硒的积累情况进行了研究。口服以及腹腔注射后，与无机硒相比，接触有机硒后观察到的浓度显著更高。在两个实验中，小脑的浓度最高，其次是大脑半球和脊髓中几乎相同的水平，这与硒的化学形式或给药途径无关。然而，每组所研究的中枢神经系统不同部位之间观察到的浓度差异并不显著。在单次腹腔注射（1.7毫克硒/千克体重）75-硒-SeMeth或NaSe后，对中枢神经系统中硒的留存情况进行了研究。在两组中，我们都观察到一个初始的快速排泄阶段，随后是一个类似于一级反应的较慢排泄阶段。单次注射后，与NaSe相比，有机硒从中枢神经系统所有部位消失的速度要慢得多。
