Delbrouck Carine, Gabius Hans-Joachim, Kaltner Herbert, Decaestecker Christine, Kiss Robert, Hassid Sergio
Ear, Nose, and Throat Department, Erasmus University Hospital, Brussels, Belgium.
Arch Otolaryngol Head Neck Surg. 2003 Jun;129(6):665-9. doi: 10.1001/archotol.129.6.665.
The term nasal polyposis describes benign growth processes in the nasal and sinus mucosa, which are mainly located in the middle meatus and never in the inferior meatus. As a step to define the biochemical determinants relevant for growth regulation, we focused on endogenous lectins known for anti-apoptotic (galectin-3) and immunomodulatory (galectin-1) activities.
Using computer-assisted microscopy, we performed an immunohistochemical investigation defining the quantitative parameters of expression of galectin-1 and galectin-3 in 10 nasal polyps, 10 middle turbinates, and 10 inferior turbinates, all of which were obtained from surgical resection.
Our data show that galectin-3 expression is markedly (P<.001) higher in nasal polyps than in turbinates. No relation to the allergic status was discovered. Galectin-1 expression is higher in nasal polyps than in middle turbinates (P<.001) in nonallergic patients compared with allergic ones (in glandular epithelium, P =.009; in connective tissue, P =.006). The lowest galectin-1 expression was observed in the middle turbinate.
These data are in line with a positive influence of galectin-3 on growth and an immunoregulatory role of galectin-1, mimicking an increased expression dependent on glucocorticoid.
鼻息肉这一术语描述的是鼻腔和鼻窦黏膜中的良性生长过程，主要位于中鼻道，从不在下鼻道。作为确定与生长调节相关的生化决定因素的一个步骤，我们聚焦于以内源性凝集素，它们具有抗凋亡（半乳糖凝集素-3）和免疫调节（半乳糖凝集素-1）活性而闻名。
我们使用计算机辅助显微镜进行了一项免疫组织化学研究，确定了从手术切除获得的10个鼻息肉、10个中鼻甲和10个下鼻甲中半乳糖凝集素-1和半乳糖凝集素-3表达的定量参数。
我们的数据显示，鼻息肉中的半乳糖凝集素-3表达明显（P<0.001）高于鼻甲。未发现与过敏状态有关。与过敏患者相比，非过敏患者鼻息肉中的半乳糖凝集素-1表达高于中鼻甲（P<0.001）（在腺上皮中，P = 0.
