Otorhinolaryngology and head & neck surgery department of Famerp, São José do Rio Preto, SP.
Braz J Otorhinolaryngol. 2010 Mar-Apr;76(2):213-8. doi: 10.1590/S1808-86942010000200011.
Rhinosinusal polyps physiopathology is not fully understand, despite numerous hypotheses regarding its inflammatory process.
A prospective study regarding the gene expression of proteins: anexin-1 and galectin-1, which has an anti-inflammatory action and is modulated by steroids.
Eleven patients with rhinosinusal polyps suffered a biopsy of their polyps at two moments: in the absence of systemic steroids and during its use. In the two samples we assessed the expression of these genes and compared it to the normal nasal mucosa in the middle meatus.
We noticed that the mean expression of the genes which code anexin-1 and galectin-1 was predominantly increased, regardless of the use of steroids in relation to the control nasal mucosa. Notwithstanding, in polyps without the use of steroids, the mean gene expression of anexin-1 was significantly higher than in the polyps which were under the use of steroids. Regarding galectin-1, there was no significant difference between the expression mean values before and after the use of systemic steroids.
The genes present an expression increase in the polyp mucosa, regardless of the use of steroids; nonetheless, the relationship of these two genes of anti-inflammatory proteins with steroids did not happen the same way.
研究具有抗炎作用且受类固醇调节的蛋白质 annexin-1 和半乳糖凝集素-1 的基因表达。
11 名鼻息肉患者在两次手术中对息肉进行活检：一次是在没有全身使用类固醇时，另一次是在使用时。在两个样本中，我们评估了这些基因的表达情况，并将其与中鼻甲的正常鼻黏膜进行了比较。
我们注意到，编码 annexin-1 和半乳糖凝集素-1 的基因的平均表达均明显增加，而与对照组相比，无论是否使用类固醇。然而，在未使用类固醇的息肉中，annexin-1 的平均基因表达明显高于使用类固醇的息肉。关于半乳糖凝集素-1，在使用全身类固醇前后，其表达均值无显著差异。
无论是否使用类固醇，息肉黏膜中这些基因的表达均增加；然而，这两种抗炎蛋白基因与类固醇的关系并非如此。
