Gross D, Shenkman Z, Bleiberg B, Dayan M, Gittelson M, Efrat R
Respiratory Rehabilitation Unit, Tel Aviv Sourasky Medical Center, 6 Weitzmann Street, Tel Aviv 93715, Israel.
Monaldi Arch Chest Dis. 2002 Oct-Dec;57(5-6):242-6.
Ginseng is a root that has been used to treat patients with various illnesses for the last 2000 years. The purpose of this study was to evaluate the effects of Ginseng extract (G115) on Pulmonary Function Tests (PFTs), Maximum Voluntary Ventilation (MVV), Maximum Inspiratory Pressure (MIP) and Maximal Oxygen Consumption (VO2max) in patients with moderately-severe Chronic Obstructive Pulmonary Disease (COPD). Ninety-two adults were randomly divided into the experimental (n = 49, G115 100 mg bid for three months) and placebo-control (n = 43) groups. PFTs, MVV and MIP were studied before treatment and every two weeks for the 3-month-study period. Exercise test and VO2max measurements were performed before the beginning and after six weeks and three months. P lower than 0.05 was considered significant. Baseline demographics and pulmonary parameters were similar between the groups. In the experimental, but not in the control group, all parameters significantly increased above baseline and compared with the placebo group. Maximum increase, compared with baseline was FVC-32.5%, FEV1.0-27.0%, PEF-27.5%, FEF50-45.4%, FEF75-56.9%, MVV-40.4%, MIP-47.0% and VO2max-37.5%. No side effects were observed. G115 100 mg bid for three months, but not placebo, improved PFTs, MVV, MIP and VO2 max in patients with moderately-severe COPD with no side effects.
在过去的2000年里，人参根一直被用于治疗各种疾病的患者。本研究的目的是评估人参提取物（G115）对中重度慢性阻塞性肺疾病（COPD）患者肺功能测试（PFT）、最大自主通气量（MVV）、最大吸气压力（MIP）和最大耗氧量（VO2max）的影响。92名成年人被随机分为实验组（n = 49，G115 100 mg，每日两次，共三个月）和安慰剂对照组（n = 43）。在治疗前以及为期3个月的研究期间每两周对PFT、MVV和MIP进行研究。在开始前、六周后和三个月后进行运动测试和VO2max测量。P值低于0.05被认为具有显著性。两组之间的基线人口统计学和肺参数相似。在实验组而非对照组中，所有参数均显著高于基线水平，且与安慰剂组相比也有显著提高。与基线相比，最大增幅为：用力肺活量（FVC）-32.5%、第1秒用力呼气容积（FEV1.0）-27.0%、呼气峰值流速（PEF）-27.5%、50%用力呼气流量（FEF50）-45.4%、75%用力呼气流量（FEF75）-56.9%、MVV-40.4%、MIP-47.0%和VO2max-37.5%。未观察到副作用。对于中重度COPD患者，每日两次服用100 mg G115，持续三个月，可改善PFT、MVV、MIP和VO2max，且无副作用，而安慰剂则无此效果。
