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超高效液相色谱-四极杆飞行时间质谱联用技术引导下从野生人参中分离抗慢性阻塞性肺疾病人参皂苷

UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng.

作者信息

Zhu Hailin, Liu Junli, Lin Hongqiang, Zhang Ying, Yang Na, Zhou Baisong, Wang Zhongyao, Chen-Yu Hsu Alan, Liu Jinping, Li Pingya

机构信息

School of Pharmaceutical Sciences, Jilin University Fujin Road 1266 Changchun 130021 Jilin China

The First Hospital of Jilin University Changchun 130021 Jilin China.

出版信息

RSC Adv. 2019 Nov 26;9(66):38658-38668. doi: 10.1039/c9ra06635g. eCollection 2019 Nov 25.

DOI:10.1039/c9ra06635g
PMID:35540186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075943/
Abstract

Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.

摘要

通过超高效液相色谱-四极杆飞行时间质谱（UPLC-QTOF-MS）引导的分级分离程序，从野生人参中分离出四种先前未描述的人参皂苷以及五种已知类似物。基于光谱和光谱数据（一维和二维核磁共振、高分辨率电喷雾电离质谱）阐明了它们的结构。分离出的化合物可显著抑制香烟烟雾提取物（CSE）诱导的A549细胞炎症反应。组蛋白去乙酰化酶2（HDAC2）途径可能参与了对A549细胞中CSE介导的炎症反应的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/6a787e46cdf2/c9ra06635g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/70a0a3ea57f7/c9ra06635g-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/2701a5d2ec76/c9ra06635g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/50103d5fcb8c/c9ra06635g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/6a787e46cdf2/c9ra06635g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/70a0a3ea57f7/c9ra06635g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/2383fadcad8c/c9ra06635g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/a940ad2e9fad/c9ra06635g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/2701a5d2ec76/c9ra06635g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/50103d5fcb8c/c9ra06635g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/9075943/6a787e46cdf2/c9ra06635g-f6.jpg

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