Bilia Anna R, Bergonzi Maria C
Department of Chemistry, School of Human Health Sciences, University of Florence, Florence, Italy.
J Ginseng Res. 2020 Mar;44(2):179-193. doi: 10.1016/j.jgr.2019.06.003. Epub 2019 Jun 18.
Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. and studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.
市场上的人参产品在成分和整体质量上表现出很大的差异。这对消费者和医疗保健专业人员来说都是一个挑战，他们正在寻找高质量、可靠的人参产品，这些产品具有经过验证的安全性和有效性。在这种情况下，植物提取物标准化至关重要，因为它决定了产品质量的可重复性，而这对于评估有效性和安全性至关重要。本综述重点关注特征明确且标准化的人参提取物G115，它是草药产品中具有恒定安全性和有效性的草药制剂的一个优秀范例。几十年来，已经进行了广泛的临床前和临床研究来评估G115的有效性和安全性。对G115的研究表明其对身体机能、认知功能、新陈代谢和免疫系统有药理作用。此外，大量关于G115的临床研究，其中大多数是双盲安慰剂对照研究，强化了临床前证据的结果，并证明了这种提取物对血糖和血脂调节、慢性阻塞性肺疾病、能量、身体机能以及免疫和认知功能的有效性。临床试验和50年的市场存在证明了G115具有良好的安全性。
