从鼠到人：系统发育足迹法助力调控元件的发现。
Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements.
作者信息
Zhang Zhaolei, Gerstein Mark
机构信息
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.
出版信息
J Biol. 2003;2(2):11. doi: 10.1186/1475-4924-2-11. Epub 2003 Jun 6.
Abstract
Phylogenetic footprinting is an approach to finding functionally important sequences in the genome that relies on detecting their high degrees of conservation across different species. A new study shows how much it improves the prediction of gene-regulatory elements in the human genome.
摘要
系统发育足迹法是一种在基因组中寻找功能重要序列的方法，该方法依赖于检测这些序列在不同物种间的高度保守性。一项新研究展示了它在改善人类基因组中基因调控元件预测方面的成效。
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