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甘草甜素，甘草根的一种活性成分，与严重急性呼吸综合征相关冠状病毒的复制

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.

作者信息

Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr H W

机构信息

Institute of Medical Virology, Frankfurt University Medical School, Paul-Ehrlich Str 40, D-60596, Frankfurt, Germany.

出版信息

Lancet. 2003 Jun 14;361(9374):2045-6. doi: 10.1016/s0140-6736(03)13615-x.

DOI:10.1016/s0140-6736(03)13615-x
PMID:12814717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7112442/
Abstract

The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.

摘要

严重急性呼吸综合征（SARS）的爆发促使人们寻找抗病毒化合物来治疗该疾病。目前，尚未确定针对SARS相关冠状病毒感染的特异性治疗方法。我们评估了利巴韦林、6-氮杂尿苷、吡唑呋林、霉酚酸和甘草甜素对从德国法兰克福大学临床中心收治的SARS患者中分离出的两株冠状病毒（FFM-1和FFM-2）的抗病毒潜力。在所有这些化合物中，甘草甜素在抑制SARS相关病毒复制方面活性最强。我们的研究结果表明，应评估甘草甜素对SARS的治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab5/7112442/80f6defb66f3/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab5/7112442/80f6defb66f3/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab5/7112442/80f6defb66f3/gr1_lrg.jpg

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