Joyce P R, Hawes C R, Mulder R T, Sellman J D, Wilson D A, Boswell D R
University Department of Psychological Medicine, Christchurch School of Medicine, New Zealand.
Biol Psychiatry. 1992 Dec 1;32(11):1035-41. doi: 10.1016/0006-3223(92)90065-8.
Levels of acute phase and other plasma proteins were measured in 21 men with major depression, 28 men with alcohol dependence, and 12 men who acted as controls. The depressed men had significantly elevated levels of the acute phase proteins, haptoglobin and alpha-1-antichymotrypsin, and of immunoglobulin G. The elevations in haptoglobin and alpha-1-antichymotrypsin were highly correlated with each other, and were correlated with the severity of depression and negatively correlated with the thyroid stimulating hormone response to thyrotropin. The alcoholic men had elevated haptoglobin levels, but significantly decreased levels of immunoglobulin G. These findings provide further evidence for an inflammatory response during depression.
对21名重度抑郁症男性、28名酒精依赖男性和12名作为对照的男性进行了急性期及其他血浆蛋白水平检测。抑郁症男性的急性期蛋白、触珠蛋白和α-1抗糜蛋白酶以及免疫球蛋白G水平显著升高。触珠蛋白和α-1抗糜蛋白酶的升高彼此高度相关，且与抑郁症严重程度相关，与促甲状腺激素对促甲状腺素的反应呈负相关。酗酒男性的触珠蛋白水平升高，但免疫球蛋白G水平显著降低。这些发现为抑郁症期间的炎症反应提供了进一步证据。
