Lenhard Boris, Wahlestedt Claes, Wasserman Wyeth W
Center for Genomics and Bioinformatics, Karolinska Institutet, 17177 Stockholm, Sweden.
Genome Res. 2003 Jun;13(6B):1501-4. doi: 10.1101/gr.951403.
GeneLynx Mouse is a meta-database providing an extensive collection of hyperlinks to mouse gene-specific information in diverse databases available via the Internet. The GeneLynx project is based on the simple notion that given any gene-specific identifier (e.g., accession number, gene name, text, or sequence), scientists should be able to access a single location that provides a set of links to all the publicly available information pertinent to the specified gene. The recent climax in the mouse genome and RIKEN cDNA sequencing projects provided the data necessary for the development of a gene-centric mouse information portal based on the GeneLynx ideals. Clusters of RIKEN cDNA sequences were used to define the initial set of mouse genes. Like its human counterpart, GeneLynx Mouse is designed as an extensible relational database with an intuitive and user-friendly Web interface. Data is automatically extracted from diverse resources, using appropriate approaches to maximize the coverage. To promote cross-database interoperability, an indexing utility is provided to facilitate the establishment of hyperlinks in external databases. As a result of the integration of the human and mouse systems, GeneLynx now serves as a powerful comparative genomics data mining resource. GeneLynx Mouse can be freely accessed at http://mouse.genelynx.org.
基因链接小鼠数据库是一个元数据库，它提供了大量超链接，可通向互联网上各种数据库中特定于小鼠基因的信息。基因链接项目基于一个简单的理念：给定任何特定于基因的标识符（例如登录号、基因名称、文本或序列），科学家应该能够访问一个单一位置，该位置提供一组通向与指定基因相关的所有公开可用信息的链接。小鼠基因组和日本理化学研究所cDNA测序项目最近取得的成果，为基于基因链接理念开发以基因为中心的小鼠信息门户提供了必要的数据。日本理化学研究所cDNA序列簇被用于定义小鼠基因的初始集。与人类版本类似，基因链接小鼠数据库被设计为一个具有直观且用户友好的网络界面的可扩展关系数据库。数据使用适当方法从各种资源中自动提取，以实现最大程度的覆盖。为促进跨数据库的互操作性，提供了一个索引实用工具，以方便在外部数据库中建立超链接。由于人类和小鼠系统的整合，基因链接现在成为了一个强大的比较基因组学数据挖掘资源。可通过http://mouse.genelynx.org免费访问基因链接小鼠数据库。
