Stamler J S, Singel D J, Loscalzo J
Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Science. 1992 Dec 18;258(5090):1898-902. doi: 10.1126/science.1281928.
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
一氧化氮（NO.）是一种潜在的有毒分子，已被认为具有广泛的生物学功能。然而，其生物化学细节仍知之甚少。一氧化氮（NO）更广泛的化学性质涉及一系列具有独特性质和反应活性的氧化还原物种：NO⁺（硝鎓离子）、NO.和NO⁻（硝酰阴离子）。将这种化学性质与当前对NO生物学的认识相结合，阐明了NO生物化学的许多方面，包括合成的酶促机制、在生物系统中的运输和靶向模式、减轻其毒性的方式以及与靶蛋白的功能调节相互作用。
