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离子通道中的电磁门控

Electromagnetic gating in ion channels.

作者信息

McLeod B R, Liboff A R, Smith S D

机构信息

Department of Electrical Engineering, Montana State University, Bozeman 59717-0378.

出版信息

J Theor Biol. 1992 Sep 7;158(1):15-31. doi: 10.1016/s0022-5193(05)80646-0.

DOI:10.1016/s0022-5193(05)80646-0
PMID:1282185
Abstract

There have been many attempts to develop a theoretical explanation of the phenomena of electromagnetic field interactions with biological systems. None of the reported efforts have been entirely successful in accounting for the observed experimental results, in particular with respect to the reports of interactions between extremely low frequency (ELF) magnetic fields and biological systems at ion cyclotron resonance frequencies. The approach used in this paper starts with the Lorentz force equation, but use is made of cylindrical co-ordinates and cylindrical boundary conditions in an attempt to more closely model the walls of an ion channel. The equations of motion of an ion that result from this approach suggest that the inside shape of the channel plus the ELF magnetic fields at specific frequencies and amplitudes could act as a gate to control the movement of the ion across the cell membrane.

摘要

人们进行了许多尝试,以对电磁场与生物系统相互作用的现象给出理论解释。在解释所观察到的实验结果方面,尤其是在解释极低频(ELF)磁场与处于离子回旋共振频率的生物系统之间的相互作用报告时,已报道的所有努力均未完全成功。本文所采用的方法始于洛伦兹力方程,但采用了柱坐标和柱形边界条件,试图更精确地模拟离子通道的壁。由该方法得出的离子运动方程表明,通道的内部形状加上特定频率和幅度的极低频磁场可作为控制离子跨细胞膜移动的门。

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