1-取代中氮茚的抗分枝杆菌活性。
Antimycobacterial activity of 1-substituted indolizines.
作者信息
Gundersen Lise-Lotte, Negussie Ayele H, Rise Frode, ØStby Ole Benny
机构信息
Department of Chemistry, University of Oslo, Blindern, Norway.
出版信息
Arch Pharm (Weinheim). 2003 Jun;336(3):191-5. doi: 10.1002/ardp.200390019.
PMID:12822185
Abstract
Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 microg/mL
摘要
使用微孔板阿尔玛蓝检测法，在BACTEC 12B培养基中对中氮茚衍生物作为抗分枝杆菌药物针对结核分枝杆菌H(37)Rv（ATCC 27294）进行了测试。所检测的最具活性的化合物在中氮茚的1位带有一个α-羟基苄基取代基。这些化合物对结核分枝杆菌的最低抑菌浓度为6.25微克/毫升
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