Ma Yangyang, Zhang Hua, Du Xiaoxiao, Fang Shurui, Yin Kexin, Du Gangfeng, Tian Zhengshan, Zhou Zhonghao
School of Chemical & Environmental Engineering, Pingdingshan University, Pingdingshan 467000, China.
College of Medicine, Pingdingshan University, Pingdingshan 467000, China.
Molecules. 2024 Dec 16;29(24):5927. doi: 10.3390/molecules29245927.
An effective method for the construction of functionalized indolizines has been developed in which β,β-difluoro peroxides act as novel C2-building blocks to implement [3+2] annulation with pyridinium ylides under base-mediated conditions. With this protocol, a broad range of multisubstituted indolizines were prepared in moderate to good yields under mild conditions, and many useful functional groups were tolerated.
已开发出一种构建官能化中氮茚的有效方法，其中β,β-二氟过氧化物作为新型C2构建单元，在碱介导的条件下与吡啶叶立德进行[3+2]环化反应。通过该方法，在温和条件下以中等至良好的产率制备了多种多取代中氮茚，并且许多有用的官能团都能兼容。
