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[实验性脉络膜新生血管的激光光凝术。2. 染料激光与氩蓝绿激光效果的比较]

[Laser photocoagulation of experimentally produced choroidal neovascularization. 2. Comparison of effects by dye and argon blue-green lasers].

作者信息

Yamada K, Takahashi K, Ohkuma H, Yamagishi K, Nishimura T, Uyama M

机构信息

Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1992 Nov;96(11):1394-404.

PMID:1282293
Abstract

Choroidal neovascularization was produced in 18 eyes of 12 rhesus monkeys by application of intense krypton laser photocoagulation. Eight weeks or later, a total of 34 choroidal neovascularizations were treated either by dye laser at wavelengths of 577 or 630 nm or by argon blue-green laser. The treated lesions were evaluated clinically and histopathologically from 24 hours to 3 months after treatment. All the treated lesions were apparently healed by each of the 3 laser modalities. Histopathologically, all the treated choroidal neovascularizations were occluded 24 hours after treatment. At 2 weeks to 3 months after treatment, newly-formed choroidal vessels were present in 3 of 9 lesions (33%) after 577 nm dye laser treatment, in 8 of 9 lesions (89%) after 630 nm dye laser treatment, and in 5 of 8 lesions (62%) after argon blue-green laser. These results seemed to show the clinical superiority of 577 nm dye laser in treating choroidal neovascularization.

摘要

通过应用强氪激光光凝术,在12只恒河猴的18只眼中诱导脉络膜新生血管形成。8周或更长时间后,共34处脉络膜新生血管接受了波长为577或630nm的染料激光或氩蓝绿激光治疗。在治疗后24小时至3个月对治疗的病变进行临床和组织病理学评估。所有治疗的病变通过三种激光方式中的任何一种均明显愈合。组织病理学上,所有治疗的脉络膜新生血管在治疗后24小时被阻塞。在治疗后2周-3个月,577nm染料激光治疗的9处病变中有3处(33%)出现新形成的脉络膜血管,630nm染料激光治疗的9处病变中有8处(89%)出现新形成的脉络膜血管,氩蓝绿激光治疗的8处病变中有5处(62%)出现新形成的脉络膜血管。这些结果似乎显示了577nm染料激光在治疗脉络膜新生血管方面的临床优势。

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