脑膜皮型脑膜瘤的黑素细胞定植：组织病理学和超微结构发现及其免疫组化和遗传学相关性：病例报告
Melanocytic colonization of a meningothelial meningioma: histopathological and ultrastructural findings with immunohistochemical and genetic correlation: case report.
作者信息
Nestor Scott L, Perry Arie, Kurtkaya Ozlem, Abell-Aleff Patrice, Rosemblat Aldo M, Burger Peter C, Scheithauer Bernd W
机构信息
Department of Pathology, West Virginia University, Morgantown, West Virginia 26506, USA.
出版信息
Neurosurgery. 2003 Jul;53(1):211-4; discussion 214-5. doi: 10.1227/01.neu.0000068990.79680.f6.
OBJECTIVE AND IMPORTANCE
Melanocytic colonization of nonpigmented extracranial tumors has been reported in adenocarcinomas, squamous cell carcinomas, skin appendage tumors, and dermatofibrosarcoma protuberans. To our knowledge, melanocytic colonization of a meningioma has not previously been described.
CLINICAL PRESENTATION
We report an unusual case of a 70-year-old African-American woman who presented with a large frontoparietal meningioma that extended through the calvarium.
INTERVENTION
Craniotomy with gross total resection of the tumor was performed. Histochemistry, immunocytochemistry, ultrastructural analysis, and molecular genetic study via fluorescence in situ hybridization confirmed melanocytic colonization of a meningothelial meningioma.
CONCLUSION
With the inclusion of meningothelial meningioma, the spectrum of tumors affected by melanocytic colonization continues to expand.
目的与重要性
在腺癌、鳞状细胞癌、皮肤附属器肿瘤和隆突性皮肤纤维肉瘤中，已报道有非色素性颅外肿瘤的黑素细胞定植。据我们所知，此前尚未描述过脑膜瘤的黑素细胞定植情况。
临床表现
我们报告了一例不寻常的病例，一名70岁的非裔美国女性，患有一个巨大的额顶叶脑膜瘤，该肿瘤已延伸至颅骨。
干预措施
实施了开颅手术并对肿瘤进行了全切除。通过组织化学、免疫细胞化学、超微结构分析以及荧光原位杂交进行的分子遗传学研究证实了脑膜内皮型脑膜瘤存在黑素细胞定植。
结论
随着脑膜内皮型脑膜瘤的纳入，受黑素细胞定植影响的肿瘤谱持续扩大。
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