Zemla Adam
Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA.
Nucleic Acids Res. 2003 Jul 1;31(13):3370-4. doi: 10.1093/nar/gkg571.
We present the LGA (Local-Global Alignment) method, designed to facilitate the comparison of protein structures or fragments of protein structures in sequence dependent and sequence independent modes. The LGA structure alignment program is available as an online service at http://PredictionCenter.llnl.gov/local/lga. Data generated by LGA can be successfully used in a scoring function to rank the level of similarity between two structures and to allow structure classification when many proteins are being analyzed. LGA also allows the clustering of similar fragments of protein structures.
我们提出了局部-全局比对(LGA)方法,该方法旨在便于以序列依赖和序列独立模式比较蛋白质结构或蛋白质结构片段。LGA结构比对程序可作为在线服务在http://PredictionCenter.llnl.gov/local/lga获取。LGA生成的数据可成功用于评分函数,以对两个结构之间的相似性水平进行排名,并在分析多个蛋白质时进行结构分类。LGA还允许对蛋白质结构的相似片段进行聚类。