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Toucan: deciphering the cis-regulatory logic of coregulated genes.巨嘴鸟：解析共调控基因的顺式调控逻辑
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2
Identification and functional analysis of human transcriptional promoters.人类转录启动子的鉴定与功能分析。
Genome Res. 2003 Feb;13(2):308-12. doi: 10.1101/gr.794803.
3
Computational analysis of core promoters in the Drosophila genome.果蝇基因组中核心启动子的计算分析。
Genome Biol. 2002;3(12):RESEARCH0087. doi: 10.1186/gb-2002-3-12-research0087. Epub 2002 Dec 20.
4
NCBI Reference Sequence project: update and current status.美国国立生物技术信息中心参考序列项目：更新与现状
Nucleic Acids Res. 2003 Jan 1;31(1):34-7. doi: 10.1093/nar/gkg111.
5
Database resources of the National Center for Biotechnology.国家生物技术信息中心的数据库资源。
Nucleic Acids Res. 2003 Jan 1;31(1):28-33. doi: 10.1093/nar/gkg033.
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.超过15000条全长人类和小鼠cDNA序列的生成与初步分析。
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.基于60770个全长cDNA功能注释的小鼠转录组分析。
Nature. 2002 Dec 5;420(6915):563-73. doi: 10.1038/nature01266.
8
Initial sequencing and comparative analysis of the mouse genome.小鼠基因组的初步测序与比较分析。
Nature. 2002 Dec 5;420(6915):520-62. doi: 10.1038/nature01262.
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Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering.通过模糊k均值聚类探索酵母基因表达的条件共调控
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PromoSer：一项大规模的哺乳动物启动子和转录起始位点识别服务。

PromoSer: A large-scale mammalian promoter and transcription start site identification service.

作者信息

Halees Anason S, Leyfer Dmitriy, Weng Zhiping

机构信息

Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA.

出版信息

Nucleic Acids Res. 2003 Jul 1;31(13):3554-9. doi: 10.1093/nar/gkg549.

DOI:10.1093/nar/gkg549
PMID:12824364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC168956/
Abstract

Proximal promoters have a major impact on transcriptional regulation. Studies of the sequence-based nature of this regulation usually require collection of proximal promoter sequences for large sets of co-regulated genes. We report a newly implemented web service that facilitates extraction of user specified regions around the transcription start site of all annotated human, mouse or rat genes. The transcription start sites have been identified computationally by considering alignments of a large number of partial and full-length mRNA sequences to genomic DNA, with provision for alternative promoters. The service is publicly available at http://biowulf.bu.edu/zlab/PromoSer/.

摘要

近端启动子对转录调控具有重大影响。对这种调控基于序列的性质进行研究通常需要收集大量共同调控基因的近端启动子序列。我们报告了一项新实施的网络服务，该服务有助于提取所有注释的人类、小鼠或大鼠基因转录起始位点周围用户指定的区域。转录起始位点是通过考虑大量部分和全长mRNA序列与基因组DNA的比对，并考虑到替代启动子而通过计算确定的。该服务可在http://biowulf.bu.edu/zlab/PromoSer/上公开获取。