PromoSer：一项大规模的哺乳动物启动子和转录起始位点识别服务。
PromoSer: A large-scale mammalian promoter and transcription start site identification service.
作者信息
Halees Anason S, Leyfer Dmitriy, Weng Zhiping
机构信息
Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
出版信息
Nucleic Acids Res. 2003 Jul 1;31(13):3554-9. doi: 10.1093/nar/gkg549.
Abstract
Proximal promoters have a major impact on transcriptional regulation. Studies of the sequence-based nature of this regulation usually require collection of proximal promoter sequences for large sets of co-regulated genes. We report a newly implemented web service that facilitates extraction of user specified regions around the transcription start site of all annotated human, mouse or rat genes. The transcription start sites have been identified computationally by considering alignments of a large number of partial and full-length mRNA sequences to genomic DNA, with provision for alternative promoters. The service is publicly available at http://biowulf.bu.edu/zlab/PromoSer/.
摘要
近端启动子对转录调控具有重大影响。对这种调控基于序列的性质进行研究通常需要收集大量共同调控基因的近端启动子序列。我们报告了一项新实施的网络服务，该服务有助于提取所有注释的人类、小鼠或大鼠基因转录起始位点周围用户指定的区域。转录起始位点是通过考虑大量部分和全长mRNA序列与基因组DNA的比对，并考虑到替代启动子而通过计算确定的。该服务可在http://biowulf.bu.edu/zlab/PromoSer/上公开获取。
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