Markhorst D G, van Genderingen H R, Leenhoven T, van Vught A J
Pediatric Intensive Care Unit, University Medical Center Utrecht, The Netherlands.
J Med Eng Technol. 2003 May-Jun;27(3):128-32.
To describe and validate a system for integrated measurement of ventilator settings and dependent physiological variables during high-frequency oscillatory ventilation (HFOV). A custom interface was built for data acquisition. Lung volume change was determined by respirator inductive plethysmography (RIP), modified to sampling rates of 140 Hz. Blood gas analysis was obtained using a continuous intra-arterial blood gas monitoring system. FIO2 was measured by means of an electrochemical sensor. Pressure at the airway opening and trachea (microtip transducer) were sampled. The data acquired were sent to a laptop computer for analysis, display and storage. The system was tested during a lung recruitment procedure in an animal model of respiratory distress. Linearity of the RIP was checked by gas volume injection using a supersyringe. The system operated successfully. Agreement between RIP-measured volume with injected volume was excellent; bias was 5 ml; limits of agreement were 1-9 ml. Graphs were obtained, showing the relationship between imposed mean airway pressure and lung volume change, and oxygenation. The integration of ventilator settings and dependent physiological variables may provide useful information for clinical, instructional and research application.
描述并验证一种用于在高频振荡通气（HFOV）期间综合测量通气机设置和相关生理变量的系统。构建了一个用于数据采集的定制接口。肺容积变化通过呼吸感应体积描记法（RIP）确定，并将采样率修改为140 Hz。使用连续动脉内血气监测系统进行血气分析。通过电化学传感器测量吸入氧分数（FIO2）。对气道开口和气管处的压力（微尖端传感器）进行采样。采集到的数据被发送到笔记本电脑进行分析、显示和存储。该系统在呼吸窘迫动物模型的肺复张过程中进行了测试。使用超级注射器通过气体注入检查RIP的线性。该系统运行成功。RIP测量体积与注入体积之间的一致性非常好；偏差为5 ml；一致性界限为1 - 9 ml。获得了图表，显示了施加的平均气道压力与肺容积变化以及氧合之间的关系。通气机设置和相关生理变量的整合可为临床、教学和研究应用提供有用信息。
