Xia Meng-Yuan, Yang Jun, Zhang Pan-Hua, Li Xiao-Nian, Luo Ji-Feng, Long Chun-Lin, Wang Yue-Hu
Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw, 05282, Myanmar.
Nat Prod Bioprospect. 2018 Dec;8(6):419-430. doi: 10.1007/s13659-018-0180-z. Epub 2018 Aug 2.
One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A-F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A-C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF). (-)-Mangochinine, pellitorine, and (2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF, with IC values of 470.3 µg/mL, 614.9 µg/mL, and 579.7 µg/mL, respectively.
从多脉胡椒的地上部分分离出一种未描述的酰胺类化合物——多脉胡椒碱A、两种未描述的异喹啉生物碱——多脉胡椒碱B和C、六种未描述的二肽——多脉胡椒酰胺A - F，以及28种已知化合物。基于一维和二维核磁共振及质谱数据分析阐明了这些未描述化合物的结构。此外，通过单晶X射线衍射分析确认了多脉胡椒碱A - C的结构。对所有分离物进行了抗凝血酶（IIa）或血小板活化因子（PAF）诱导的血小板聚集抑制活性评估。（-）-芒果宁、派立托宁和（2E，4E）-N - 异丁基 - 2,4 - 十二碳二烯酰胺对PAF诱导的兔血小板聚集表现出较弱的抑制活性，IC值分别为470.3 μg/mL、614.9 μg/mL和579.7 μg/mL。
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