Bothamley G, Batra H, Ramesh V, Chandramui A, Ivanyi J
MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, UK.
Eur J Clin Microbiol Infect Dis. 1992 Oct;11(10):912-5. doi: 10.1007/BF01962372.
Previous studies in UK subjects suggested that the 19 kDa protein antigen of Mycobacterium tuberculosis might be valuable in the serodiagnosis of paucibacillary tuberculosis. In this study, antibody titres for the 19 kDa antigen were higher in healthy controls in India than in the UK. Consequently, the diagnostic sensitivity of this antigen and its TB23 epitope was negligible in Indian patients with tuberculosis. However, a diagnostic sensitivity of 50% was achieved in patients with skin tuberculosis on the basis of a high ratio between antibody titres for the whole antigen and its TB23 epitope.
此前针对英国受试者的研究表明，结核分枝杆菌的19 kDa蛋白抗原可能在少菌型结核病的血清学诊断中具有重要价值。在本研究中，印度健康对照人群中针对19 kDa抗原的抗体滴度高于英国。因此，该抗原及其TB23表位在印度结核病患者中的诊断敏感性可忽略不计。然而，基于全抗原及其TB23表位的抗体滴度之间的高比率，皮肤结核患者的诊断敏感性达到了50%。
