Buchanan J R, Kleinstreuer C, Hyun S, Truskey G A
Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3211 Broughton Hall, Raleigh, NC 27695-7910, USA.
J Biomech. 2003 Aug;36(8):1185-96. doi: 10.1016/s0021-9290(03)00088-5.
Employing the rabbit's abdominal aorta as a suitable atherosclerotic model, transient three-dimensional blood flow simulations and monocyte deposition patterns were used to evaluate the following hypotheses: (i) simulation of monocyte transport through a model of the rabbit abdominal aorta yields cell deposition patterns similar to those seen in vivo, and (ii) those deposition patterns are correlated with hemodynamic wall parameters related to atherosclerosis. The deposition pattern traces a helical shape down the aorta with local elevation in monocyte adhesion around vessel branches. The cell deposition pattern was altered by an exercise waveform with fewer cells attaching in the upper abdominal aorta but more attaching around the renal orifices. Monocyte deposition was correlated with the wall shear stress gradient and the wall shear stress angle gradient. The wall stress gradient, the wall shear stress angle gradient and the normalized monocyte deposition fraction were correlated with the distribution of monocytes along the abdominal aorta and monocyte deposition is correlated with the measured distribution of monocytes around the major abdominal branches in the cholesterol-fed rabbit. These results suggest that the transport and deposition pattern of monocytes to arterial endothelium plays a significant role in the localization of lesions.
以兔腹主动脉作为合适的动脉粥样硬化模型，通过瞬态三维血流模拟和单核细胞沉积模式来评估以下假设：（i）通过兔腹主动脉模型模拟单核细胞运输产生的细胞沉积模式与体内观察到的相似，且（ii）这些沉积模式与动脉粥样硬化相关的血流动力学壁参数相关。沉积模式沿主动脉呈螺旋状，在血管分支周围单核细胞粘附局部升高。运动波形改变了细胞沉积模式，上腹部主动脉附着的细胞较少，而肾口周围附着的细胞较多。单核细胞沉积与壁面切应力梯度和壁面切应力角梯度相关。壁应力梯度、壁面切应力角梯度和标准化单核细胞沉积分数与沿腹主动脉的单核细胞分布相关，且单核细胞沉积与胆固醇喂养兔腹部主要分支周围单核细胞的测量分布相关。这些结果表明，单核细胞向动脉内皮的运输和沉积模式在病变定位中起重要作用。
