Ott G, Ott M M, Gärtner C, Müller-Hermelink H K
Pathologisches Institut, Universität Würzburg.
Verh Dtsch Ges Pathol. 1992;76:197-201.
72 T-cell lymphomas were analyzed for the presence of Epstein-Barr virus DNA using Southern or dot blot hybridization. EBV DNA was found in 25 peripheral T-cell lymphomas and in none of 6 T-lymphoblastic tumors. A high prevalence of EBV was detected in AILD type, Lennert's, pleomorphic medium and large cell nodal lymphomas and in upper aerodigestive tract lymphoma biopsies. Clonotypic analysis revealed monoclonal as well as oligoclonal viral populations. The possible influence of EBV in lymphomagenesis, the impact of virus-mediated interactions in the B- and T-cell system and factors involving site of tumor development are discussed.
采用Southern印迹或斑点印迹杂交法对72例T细胞淋巴瘤进行了Epstein-Barr病毒（EBV）DNA检测。在25例外周T细胞淋巴瘤中发现了EBV DNA，而6例T淋巴母细胞瘤中均未发现。在血管免疫母细胞性淋巴结病（AILD）型、 Lennert淋巴瘤、多形性中大和大细胞性淋巴结淋巴瘤以及上呼吸道消化道淋巴瘤活检标本中检测到EBV的高流行率。克隆型分析显示病毒群体既有单克隆的也有寡克隆的。文中讨论了EBV在淋巴瘤发生中的可能影响、病毒介导的B细胞和T细胞系统相互作用的影响以及涉及肿瘤发生部位的因素。
