Tosti Antonella, Piraccini Bianca Maria, Pazzaglia Massimiliano, Vincenzi Colombina
Department of Dermatology, University of Bologna, Italy.
J Am Acad Dermatol. 2003 Jul;49(1):96-8. doi: 10.1067/mjd.2003.423.
Efficacy of topical steroids in alopecia areata is still discussed.
The purpose of this study was to evaluate the efficacy of clobetasol propionate 0.05% ointment under occlusion in 28 patients with alopecia areata totalis (AT) or AT/alopecia universalis.
A total of 28 patients were instructed to apply 2.5 g of clobetasol propionate to the right side of the scalp every night under occlusion with a plastic film. Treatment was performed 6 days a week for 6 months. When regrowth of terminal hair occurred, treatment was extended over the entire scalp. All patients were followed up for another 6 months.
Of the 28 patients included in the study, 8 were treated successfully (28.5%). Regrowth of terminal hair began on the treated side 6 to 14 weeks after the start of treatment. Of these 8 patients, 3 had a relapse and were not able to maintain hair regrowth.
Our study shows that clobetasol propionate 0.05% under occlusion is effective in inducing hair regrowth in patients with AT or AT/alopecia universalis. Occurrence of hair regrowth only on the treated half of the scalp clearly shows that efficacy of treatment is a result of a local and not systemic effect of the drug. Although only 17.8% of patients had long-term benefit by treatment, our results were obtained in a population of patients with severe and refractory forms of the disease.
外用糖皮质激素治疗斑秃的疗效仍存在争议。
本研究旨在评估0.05%丙酸氯倍他索软膏封包治疗28例全秃（AT）或全秃/普秃患者的疗效。
共28例患者被指导每晚在头皮右侧涂抹2.5 g丙酸氯倍他索，并用塑料薄膜封包。每周治疗6天，持续6个月。当终毛开始再生时，治疗扩展至整个头皮。所有患者均随访另外6个月。
纳入研究的28例患者中，8例治疗成功（28.5%）。治疗开始后6至14周，治疗侧开始出现终毛再生。这8例患者中，3例复发，无法维持毛发再生。
我们的研究表明，0.05%丙酸氯倍他索封包治疗对全秃或全秃/普秃患者诱导毛发再生有效。仅在治疗的半侧头皮出现毛发再生清楚地表明，治疗效果是药物局部而非全身作用的结果。尽管只有17.8%的患者通过治疗获得长期益处，但我们的结果是在患有严重难治性疾病的患者群体中获得的。
