Laitinen J, Taponen S, Martikainen H, Pouta A, Millwood I, Hartikainen A-L, Ruokonen A, Sovio U, McCarthy M I, Franks S, Järvelin M R
Oulu Regional Institute of Occupational Health, Oulu, Aapistie 1, Oulu, Finland.
Int J Obes Relat Metab Disord. 2003 Jun;27(6):710-5. doi: 10.1038/sj.ijo.0802301.
To study the association between body size from birth to adulthood and self-reported symptoms of polycystic ovary syndrome (PCOS), particularly hirsutism and menstrual disturbances.
Longitudinal, population-based study of a cohort of women born in 1966 in northern Finland. The study population included 2007 women who were not pregnant and did not use hormonal contraception. Of these 528 (26%) had self-reported symptoms of PCOS.
Weight at birth, gestational age, being small for gestational age or growth retardation at birth were not associated with PCOS symptoms at 31 y. An increased risk of PCOS symptoms was observed among women with abdominal obesity (waist/hip ratio >85th percentile) at 31 y who had normal weight in adolescence and were overweight (body mass index (BMI) 25.0-29.9 kg/m(2)) or obese (BMI>30.0 kg/m(2)) at 31 y (relative risk (RR) (95% CI) 1.44(1.10-1.89)), and among women with abdominal obesity who were overweight or obese at both 14 and 31 y (1.71 (1.30-2.24)). A total of 30% and 41% of the women with PCOS symptoms in these groups could be attributed, respectively, to overweight, obesity and abdominal obesity at 31 y.
These results suggest that obesity in adolescence and in adulthood, and also weight gain after adolescence, particularly in the presence of abdominal obesity, are associated with self-reported PCOS symptoms in adulthood. Thus, based on the results from intervention studies treating PCOS and the results of this study, the prevention of obesity and abdominal obesity is important among young women.
研究从出生到成年的体型与多囊卵巢综合征（PCOS）自我报告症状之间的关联，尤其是多毛症和月经紊乱。
对1966年出生于芬兰北部的一组女性进行基于人群的纵向研究。研究人群包括2007名未怀孕且未使用激素避孕的女性。其中528名（26%）有PCOS自我报告症状。
出生体重、胎龄、小于胎龄儿或出生时生长迟缓与31岁时的PCOS症状无关。在31岁时腹部肥胖（腰臀比>第85百分位数）、青春期体重正常且31岁时超重（体重指数（BMI）25.0 - 29.9 kg/m²）或肥胖（BMI>30.0 kg/m²）的女性中，观察到PCOS症状风险增加（相对风险（RR）（95%置信区间）1.44（1.10 - 1.89）），以及在14岁和31岁时均超重或肥胖的腹部肥胖女性中（1.71（1.30 - 2.24））。在这些组中，分别有30%和41%的有PCOS症状的女性可归因于31岁时的超重、肥胖和腹部肥胖。
这些结果表明，青春期和成年期的肥胖，以及青春期后体重增加，尤其是存在腹部肥胖时，与成年期自我报告的PCOS症状相关。因此，基于治疗PCOS的干预研究结果和本研究结果，预防肥胖和腹部肥胖在年轻女性中很重要。
