Gokulakrishnan Rajasekar, Delhikumar Chinnaiah G, Senthilkumar Gandhipuram P, Sahoo Jayaprakash, Kumar Ramachandran R
Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Indian J Endocrinol Metab. 2024 Sep-Oct;28(5):542-547. doi: 10.4103/ijem.ijem_353_23. Epub 2024 Sep 4.
Childhood obesity is associated with chronic low-grade systemic inflammation, which results in obesity-related comorbidities. This study compared the inflammatory markers between obese and normal children and assessed obesity-related comorbidities.
In this cross-sectional analytical study, 40 obese children between 5-18 years of age were recruited as cases, and an equal number of age and gender-matched normal children as the control. The inflammatory markers-high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin were compared between the groups. Hypothyroidism, dyslipidemia, insulin resistance, hypertension, and nonalcoholic fatty liver disease (NAFLD) were screened among obese children.
We observed a male-female ratio of 1.5:1 in each group. The median hs-CRP between obese and normal children were 2.53 mg/L (0.94,6.85) and 0.77 mg/L (0.19,7.19), and the median IL-6 levels were 3.56 pg/ml (2.17,5.48) and 3.76 pg/ml (1.08,7.91) respectively. The median IL-10 levels between obese and control groups were 2.06 pg/ml (0.35,6.3) and 1.82 pg/ml (0.41,6.5), and the median adiponectin levels between the groups were 8.6 mcg/ml (6.65,16.04) and 9.79 mcg/ml (8.45,11.91) respectively. We didn't observe significant differences in the markers between the groups. Dyslipidemia, insulin resistance, and metabolic syndrome were seen in 80%, 52.5%, and 45% of obese children, respectively. Other comorbidities-NAFLD, hypertension, and hypothyroidism, were observed in 27.5%, 25%, and 7.5% of obese children, respectively. IL-6 had a significant positive correlation with total cholesterol (r = 0.40), LDL levels (r = 0.50), and HDL (r = 0.32).
There was no difference in inflammatory markers between obese and normal children. Dyslipidemia and insulin resistance were the most common comorbidities.
儿童肥胖与慢性低度全身炎症相关，这会导致与肥胖相关的合并症。本研究比较了肥胖儿童和正常儿童的炎症标志物，并评估了与肥胖相关的合并症。
在这项横断面分析研究中，招募了40名5至18岁的肥胖儿童作为病例组，并选取了数量相等、年龄和性别匹配的正常儿童作为对照组。比较了两组之间的炎症标志物——高敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）和脂联素。在肥胖儿童中筛查了甲状腺功能减退、血脂异常、胰岛素抵抗、高血压和非酒精性脂肪性肝病（NAFLD）。
我们观察到每组的男女比例为1.5:1。肥胖儿童和正常儿童的hs-CRP中位数分别为2.53mg/L（0.94,6.85）和0.77mg/L（0.19,7.19），IL-6水平中位数分别为3.56pg/ml（2.17,5.48）和3.76pg/ml（1.08,7.91）。肥胖组和对照组之间的IL-10水平中位数分别为2.06pg/ml（0.35,6.3）和1.82pg/ml（0.41,6.5），两组之间的脂联素水平中位数分别为8.6mcg/ml（6.65,16.04）和9.79mcg/ml（8.45,11.91）。我们未观察到两组之间这些标志物存在显著差异。80%、52.5%和45%的肥胖儿童分别出现血脂异常、胰岛素抵抗和代谢综合征。其他合并症——NAFLD、高血压和甲状腺功能减退，分别在27.5%、25%和7.5%的肥胖儿童中观察到。IL-6与总胆固醇（r = 0.40）、低密度脂蛋白水平（r = 0.50）和高密度脂蛋白（r = 0.32）呈显著正相关。
肥胖儿童和正常儿童的炎症标志物无差异。血脂异常和胰岛素抵抗是最常见的合并症。
