Department of Medical Microbiology, Poznan University of Medical Sciences, Wieniawskiego 3, 61-712 Poznan, Poland.
Earth and Life Institute (ELI), UCLouvain, Croix du Sud 2, 1348 Louvain-La-Neuve, Belgium.
Nutrients. 2022 Oct 28;14(21):4555. doi: 10.3390/nu14214555.
Polycystic ovarian syndrome (PCOS) is one of the most common heterogeneous endocrine and metabolic disorders in premenopausal women. It is a complex multifactorial disorder with strong epigenetic and environmental influences, including factors related to eating habits and lifestyle. There is a close relationship between obesity and PCOS. Weight gain and obesity are often clinical symptoms manifested by biochemical markers. Moreover, abdominal obesity in women with PCOS is involved in the development of inflammatory changes. A significant share of balanced therapies correcting the lifestyle of patients is suggested, e.g., with the implementation of appropriate diets to minimize exposure to inflammatory factors and prevent abnormal immune system stimulation. In the case of obese patients with PCOS, planning a diet program and supporting the motivation to change eating habits play an important role to lose weight and lower BMI. Probiotics/synbiotic supplementation may enhance weight loss during the diet program and additionally positively affect metabolic and inflammatory factors by improving the intestinal microbiome.
多囊卵巢综合征（PCOS）是绝经前妇女最常见的异质性内分泌和代谢紊乱之一。它是一种复杂的多因素疾病，具有强烈的表观遗传和环境影响，包括与饮食习惯和生活方式相关的因素。肥胖与 PCOS 密切相关。体重增加和肥胖通常是生化标志物表现出的临床症状。此外，PCOS 女性的腹部肥胖与炎症变化的发展有关。建议采用纠正患者生活方式的平衡疗法，例如，实施适当的饮食以最大程度地减少炎症因子的暴露并防止免疫系统异常刺激。对于肥胖的 PCOS 患者，制定饮食计划和支持改变饮食习惯的动机对于减轻体重和降低 BMI 非常重要。益生菌/合生剂补充剂可以通过改善肠道微生物组来增强饮食计划期间的体重减轻，并对代谢和炎症因子产生积极影响。
