Li Panjian
DePuy Orthopaedics Inc., 700 Othopaedic Drive, Warsaw, Indiana 46581, USA.
J Biomed Mater Res A. 2003 Jul 1;66(1):79-85. doi: 10.1002/jbm.a.10519.
Nano-apatite coating closely mimicking bone mineral was grown directly on titanium soaked in an aqueous solution containing all major inorganic components present in the body, mainly, HCO3(-), Ca(2+), HPO4(2-), and Mg(2+) ions. The removal of HCO3(-) ions from the solution in the form of CO2 resulted in the increase of solution pH. As a consequence of this reaction, the nano-apatite coating was formed on the surface of titanium with composition and structure equivalent to those of bone mineral. The biomimetic nano-apatite was demonstrated to be capable of conducting bone formation and promoting direct bone apposition. This bioactive coating also affected the behavior of human osteoblasts as indicated by their morphologies observed in cell culture study.
在浸泡于含有体内所有主要无机成分（主要为HCO3(-)、Ca(2+)、HPO4(2-)和Mg(2+)离子）的水溶液中的钛表面，直接生长出了与骨矿物质极为相似的纳米磷灰石涂层。溶液中的HCO3(-)离子以CO2的形式被去除，导致溶液pH值升高。作为该反应的结果，在钛表面形成了成分和结构与骨矿物质相当的纳米磷灰石涂层。已证明这种仿生纳米磷灰石能够引导骨形成并促进骨直接附着。在细胞培养研究中观察到的人成骨细胞形态表明，这种生物活性涂层也会影响人成骨细胞的行为。
