Penna S C, Medeiros M V, Aimbire F S C, Faria-Neto H C C, Sertié J A A, Lopes-Martins R A B
Laboratório de Farmacologia e Experimentação Animal, Instituto de Pesquisa e Desenvolvimento--IP&D, Universidade do Vale do Paraíba--UNIVAP, Urbanova, São José dos Campos, SP, Brazil.
Phytomedicine. 2003;10(5):381-5. doi: 10.1078/0944-7113-00271.
Plant extracts have been used for centuries as a popular mode of treatment for several health disorders. Over the last ten years, the study of those extracts has attracted attention in different fields of the biological sciences. Ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), is a commom constituent of diet worldwide and it has been reported that its extracts present some pharmacological activities. Here we investigate the effects of the crude hydralcoholic extract of ginger rhizomes on the classical models of rat paw and skin edema. The carrageenan-, compound 48/80- or serotonin-induced rat paw edema were inhibited significantly by the intraperitoneal administration of alcoholic ginger extract. Ginger extract was also effective in inhibiting 48/80-induced rat skin edema at doses of 0.6 and 1.8 mg/site. Rat skin edema induced by substance P or bradikinin was not affected by treatment with Z. officinalle extract. The intraperitoneal administration of ginger extract (186 mg/kg(-1) body wt.) 1 h prior to serotonin injections, reduced significantly the serotonin-induced rat skin edema. Our results demonstrated that crude extract of Zingiber officinale was able to reduce rat paw and skin edema induced by carrageenan, 48/80 compound and serotonin. The antiedematogenic activity seems to be related, at least partially, to an antagonism of the serotonin receptor.
几个世纪以来，植物提取物一直是治疗多种健康疾病的常用方法。在过去十年中，对这些提取物的研究在生物科学的不同领域引起了关注。生姜是姜科植物姜（Zingiber officinale Roscoe）的根茎，是全球饮食中的常见成分，据报道其提取物具有一些药理活性。在此，我们研究了生姜根茎的粗制水醇提取物对大鼠爪部和皮肤水肿经典模型的影响。腹腔注射酒精生姜提取物可显著抑制角叉菜胶、化合物48/80或血清素诱导的大鼠爪部水肿。生姜提取物在剂量为0.6和1.8毫克/部位时，对抑制化合物48/80诱导的大鼠皮肤水肿也有效。P物质或缓激肽诱导的大鼠皮肤水肿不受姜提取物处理的影响。在注射血清素前1小时腹腔注射生姜提取物（186毫克/千克体重），可显著减轻血清素诱导的大鼠皮肤水肿。我们的结果表明，生姜粗提取物能够减轻角叉菜胶、化合物48/80和血清素诱导的大鼠爪部和皮肤水肿。抗水肿活性似乎至少部分与血清素受体的拮抗作用有关。
