Agarwal Roshan, Kaye Stan B
Section of Medicine, Institute for Cancer Research, Sutton, Surrey SM2 5NG, UK.
Nat Rev Cancer. 2003 Jul;3(7):502-16. doi: 10.1038/nrc1123.
Ovarian cancer is responsible for 4% of deaths from cancer in women. Treatment comprises a combination of surgery and chemotherapy, but patients typically experience disease relapse within 2 years of the initial treatment. Further treatment can extend survival, although relapse eventually occurs again. A better understanding of the mechanisms that underlie this drug resistance should allow treatment to be optimized, so that substantial improvements in the outlook for women with this disease can be achieved.
卵巢癌导致4%的女性癌症死亡。治疗包括手术和化疗相结合，但患者通常在初始治疗后的2年内出现疾病复发。进一步治疗可延长生存期，尽管最终仍会再次复发。更好地了解这种耐药性的潜在机制应能使治疗得到优化，从而大幅改善这种疾病女性患者的预后。
