Nakanuma K, Moriguchi T, Suzuki H, Shinozuka K
Department of Chemistry, Faculty of Engineering, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Nucleic Acids Res Suppl. 2001(1):69-70. doi: 10.1093/nass/1.1.69.
We have previously reported that a multifunctional conjugate having the acridine derivative as an intercalative molecule and the polyamine moiety as an RNA cleaving molecule bound to a double helical RNA and cleaved the target efficiently. Along the study to develop a sequence and site specific artificial RNA cleaving molecule, we have development a novel intercalative molecule having polyamine moiety and DNA connecting function. The trisamine-acridine-tethered DNA is expected to bind to the complementary RNA and cleave the phosphodiester bond of the RNA near the position of the built-in interecalator.
