Aburomia Rami, Khaner Oded, Sidow Arend
Department of Pathology, Stanford University Medical Center, Room 248B, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.
J Struct Funct Genomics. 2003;3(1-4):45-52.
Early vertebrate evolution is characterized by a significant increase of organismal complexity over a relatively short time span. We present quantitative evidence for a high rate of increase in morphological complexity during early vertebrate evolution. Possible molecular evolutionary mechanisms that underlie this increase in complexity fall into a small number of categories, one of which is gene duplication and subsequent structural or regulatory neofunctionalization. We discuss analyses of two gene families whose regulatory and structural evolution shed light on the connection between gene duplication and increases in organismal complexity.
早期脊椎动物的进化特点是在相对较短的时间跨度内机体复杂性显著增加。我们提供了定量证据，证明早期脊椎动物进化过程中形态复杂性的高增长率。导致这种复杂性增加的可能分子进化机制可分为少数几类，其中之一是基因复制以及随后的结构或调控新功能化。我们讨论了对两个基因家族的分析，其调控和结构进化揭示了基因复制与机体复杂性增加之间的联系。
