Björntorp P
Department of Medicine, University of Göteborg, Sahlgren's Hospital, Sweden.
J Cardiovasc Pharmacol. 1992;20 Suppl 8:S26-8.
Recent studies have indicated that the waist/hip circumference ratio (WHR), an index of abdominal fat distribution, is a risk factor for cardiovascular disease and diabetes, in parallel with other previously established risk factors. Obesity, without taking fat distribution into account, seems to be associated with WHR in its relationship to the metabolic risk factors for these diseases. The important component of the WHR is probably the mass of visceral fat. This cluster of phenomena constitute what has recently been called the metabolic syndrome or syndrome X. Visceral fat mass is probably increased by a multiple endocrine aberration, where steroid hormones are important. This seems to cause insulin resistance by direct effects on the periphery, which may be amplified by the metabolism of the enlarged visceral adipose tissues.
近期研究表明，腰臀围比（WHR）作为腹部脂肪分布指标，与其他先前确定的危险因素一样，是心血管疾病和糖尿病的危险因素。不考虑脂肪分布的肥胖，在其与这些疾病代谢危险因素的关系中似乎与腰臀围比相关。腰臀围比的重要组成部分可能是内脏脂肪量。这一系列现象构成了最近被称为代谢综合征或X综合征的病症。内脏脂肪量可能因多种内分泌异常而增加，其中类固醇激素起重要作用。这似乎通过对外周的直接作用导致胰岛素抵抗，而增大的内脏脂肪组织的代谢可能会放大这种作用。
