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面部线状局灶性弹性组织变性:一例报告

Facial linear focal elastosis: a case report.

作者信息

Inaloz H Serhat, Kirtak Necmettin, Karakok Metin, Ozgoztasi Orhan

机构信息

Gaziantep University Medical Faculty, Research and Application Hospital, Gaziantep, Turkey.

出版信息

Int J Dermatol. 2003 Jul;42(7):558-60. doi: 10.1046/j.1365-4362.2003.01733.x.

Abstract

BACKGROUND

Linear focal elastosis is an uncommon disorder that clinically shows band-like stria and a histological focal increase in elastic fibers. The disorder preferentially affects men after the age of 60 years and occurs on the lower back. The pathogenesis of linear focal elastosis is still somewhat of an enigma.

METHOD

A 50-year-old farmer presented with an unusual linear lesion on the left side of his chin. The patient was frequently exposed to sun because of fieldwork for a period of more than 40 years.

RESULTS

Skin biopsy specimen revealed a massive abnormal collagen deposition extending from the subpapillary dermis to the lower dermis with numerous wavy bundles of fibers. Elastin van Gieson stain for elastic fibers showed that abnormal elastic fibers were increased within a massive abnormal collagen deposition. Diagnosis of facial linear focal elastosis was made after clinicopathological correlation.

CONCLUSION

Facial involvement of linear focal elastosis has not been reported previously in the literature. It has been suggested that sunlight has a minor role in the development of elastotic change in linear focal elastosis. However, our patient was a farmer and was exposed to sunlight frequently for a period of more than 40 years, suggesting that ultraviolet radiation may play a role in the pathogenesis of linear focal elastosis.

摘要

背景

线性局限性弹力纤维病是一种罕见的疾病,临床上表现为带状条纹,组织学上可见弹力纤维局灶性增多。该疾病好发于60岁以上男性,多见于下背部。线性局限性弹力纤维病的发病机制仍有些神秘。

方法

一名50岁的农民,其左侧下巴出现一处异常的线性皮损。由于从事田间劳作40多年,该患者经常暴露于阳光下。

结果

皮肤活检标本显示,从乳头下真皮至真皮下部有大量异常胶原沉积,伴有许多波浪状纤维束。弹力纤维的弹性蛋白-吉森染色显示,在大量异常胶原沉积内异常弹力纤维增多。经临床病理对照后诊断为面部线性局限性弹力纤维病。

结论

此前文献中尚未报道过线性局限性弹力纤维病累及面部。有人提出,阳光在 线性局限性弹力纤维病弹力变性改变的发生中作用较小。然而,我们的患者是一名农民,40多年来经常暴露于阳光下这表明紫外线辐射可能在线性局限性弹力纤维病的发病机制中起作用。

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